Statistical Analysis (POCT CYP2C19)
Scoring
The report shows the individual device scores for each sample, along with an average score across the 3 samples per survey, and an overall average score across different surveys. The scoring system used broadly reflects the clinical significance of the results obtained:
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- A correct result is given a score of 0.
- A sliding scale score between 1 and 6 is assigned for incorrectly identified results, where 6 represents a gross misclassification of the result.
- A test failure is given a score of 1, 2 or 4, depending on the sample’s cell load.
- An incorrect result is given a score of 6 or 3. A score of 6 is assigned when an incorrect diplotype is assigned. A score of 3 is given when a partially correct diplotype is assigned.
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Table: Scoring matrix
| Expected results | Participant results | Assigned Score | Adjusted score* |
| Correct Diplotype | Correct Diplotype | 0 | 0 |
| Correct Diplotype | Partially Correct Diplotype | 3 | 1.5 |
| Correct Diplotype | Incorrect Diplotype | 6 | 3 |
| Correct Diplotype | Test failed | 1,2 or 4 | 0,5 or 2 |
| Correct Diplotype | Not Submitted | 3 | 3 |
*Adjusted scores are assigned when <90% (30+ total submissions) of participants record the correct result. Adjusted scores are not applied for a total submission less than 30.
Survey performance calculation
The overall individual device performer status is determined by the average score across the 3 samples per survey, based on the following conditions:
Table: Performance status
| Average score condition (AvgS) | Performer status |
| 0 ≤ AvgS < 1 | Good |
| 1 ≤ AvgS < 2 | Acceptable |
| AvgS ≥ 2 | Poor |
For more information about report statistics please download EMQN Participant’s Manual.
